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Post-translational modifications of microtubules Wloga D; Gaertig JJ Cell Sci 2010[Oct]; 123 (Pt 20): 3447-55Microtubules--polymers of tubulin--perform essential functions, including regulation of cell shape, intracellular transport and cell motility. How microtubules are adapted to perform multiple diverse functions is not well understood. Post-translational modifications of tubulin subunits diversify the outer and luminal surfaces of microtubules and provide a potential mechanism for their functional specialization. Recent identification of a number of tubulin-modifying and -demodifying enzymes has revealed key roles of tubulin modifications in the regulation of motors and factors that affect the organization and dynamics of microtubules.|Animals[MESH]|Cilia/metabolism[MESH]|Humans[MESH]|Microtubules/*metabolism[MESH]|Models, Biological[MESH]|Protein Processing, Post-Translational[MESH]|Tubulin/metabolism[MESH] |
