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mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity Dash R; Bhutia SK; Azab B; Su ZZ; Quinn BA; Kegelmen TP; Das SK; Kim K; Lee SG; Park MA; Yacoub A; Rahmani M; Emdad L; Dmitriev IP; Wang XY; Sarkar D; Grant S; Dent P; Curiel DT; Fisher PBCytokine Growth Factor Rev 2010[Oct]; 21 (5): 381-91Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effects toward normal cells or tissues. mda-7/IL-24 was cloned from human melanoma cells by differentiation induction subtraction hybridization (DISH) and promotes endoplasmic reticulum (ER) stress culminating in apoptosis or toxic autophagy in a broad-spectrum of human cancers, when assayed in cell culture, in vivo in human tumor xenograft mouse models and in a Phase I clinical trial in patients with advanced cancers. This therapeutically active cytokine also induces indirect antitumor activity through inhibition of angiogenesis, stimulation of an antitumor immune response, and sensitization of cancer cells to radiation-, chemotherapy- and antibody-induced killing.|Amino Acid Sequence[MESH]|Animals[MESH]|Humans[MESH]|Interleukin-10/genetics/*pharmacology[MESH]|Interleukins/genetics/*pharmacology[MESH]|Molecular Sequence Data[MESH]|Neoplasms/*drug therapy[MESH] |
