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PKC-theta is a drug target for prevention of T cell-mediated autoimmunity and allograft rejection Kwon MJ; Wang R; Ma J; Sun ZEndocr Metab Immune Disord Drug Targets 2010[Dec]; 10 (4): 367-72Protein kinase C theta (PKC-theta) is a key kinase in mediating T cell receptor (TCR) signals. PKC-theta activated by T cell receptor (TCR) engagement translocates to immunological synapses and regulates the activation of transcriptional factors NFkappaB, AP-1, and NFAT. These transcription factors then activate target genes such as IL-2. T cells deficient in PKC-theta display defects in T cell activation, survival, activation-induced cell death, and the differentiation into inflammatory T cells, such as Th2 and Th17 cells both in vitro and in vivo. Since these effector T helper cells are responsible for mediating autoimmunity, selective inhibition of PKC-theta is considered a treatment for prevention of autoimmune diseases and allograft rejection.|Animals[MESH]|Autoimmune Diseases/enzymology/immunology/*prevention & control[MESH]|Autoimmunity/*drug effects[MESH]|Graft Rejection/enzymology/immunology/*prevention & control[MESH]|Humans[MESH]|Immunosuppressive Agents/*pharmacology[MESH]|Isoenzymes[MESH]|Protein Kinase C/*antagonists & inhibitors/metabolism[MESH]|Protein Kinase Inhibitors/*pharmacology[MESH]|Protein Transport[MESH]|Signal Transduction/drug effects[MESH]|T-Lymphocytes/*drug effects/enzymology/immunology[MESH]|Transplantation, Homologous[MESH] |
