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lüll Intraepithelial lymphocytes: to serve and protect Sheridan BS; Lefrancois LCurr Gastroenterol Rep 2010[Dec]; 12 (6): 513-21The mucosal immune system is constantly exposed to a wide range of commensal and potentially pathogenic microbial species. Chronic exposure to foreign organisms makes generation of an appropriate immune response critical in maintaining a balance between elimination of harmful pathogens, peaceful coexistence with commensals, and prevention of autoimmunity. Intestinal intraepithelial lymphocytes provide a first line of defense at this extensive barrier with the outside world, and as such, understanding their role in immunity is critical.|Animals[MESH]|Autoimmunity/immunology[MESH]|CD8 Antigens/immunology[MESH]|Cadherins/immunology[MESH]|Homeostasis/immunology[MESH]|Humans[MESH]|Immunologic Memory/physiology[MESH]|Interleukin-15/immunology[MESH]|Intestinal Mucosa/*immunology[MESH]|Lymphocyte Activation/immunology[MESH]|Receptors, Antigen, T-Cell, alpha-beta/immunology[MESH]|T-Lymphocytes/*immunology[MESH] |