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The employment of leukotriene antagonists in cutaneous diseases belonging to allergological field Nettis E; D'Erasmo M; Di Leo E; Calogiuri G; Montinaro V; Ferrannini A; Vacca AMediators Inflamm 2010[]; 2010 (ä): äLeukotrienes (LTs) are potent biological proinflammatory mediators. LTC4, LTD4, and LTE4 are more frequently involved in chronic inflammatory responses and exert their actions binding to a cysteinyl-LT 1 (CysLT1) receptor and a cysteinyl-LT 2 (CysLT2) receptor. LTs receptor antagonists available for clinical use demonstrate high-affinity binding to the CysLT1 receptor. In this paper the employment of anti-LTs in allergic cutaneous diseases is analyzed showing that several studies have recently reported a beneficial effects of these agents (montelukast and zafirlukast as well as zileuton) for the treatment of some allergic cutaneous related diseases-like chronic urticaria and atopic eczema although their proper application remains to be established.|Acetates/therapeutic use[MESH]|Animals[MESH]|Cyclopropanes[MESH]|Humans[MESH]|Hypersensitivity/*drug therapy[MESH]|Indoles[MESH]|Leukotriene Antagonists/*therapeutic use[MESH]|Phenylcarbamates[MESH]|Quinolines/therapeutic use[MESH]|Skin Diseases/*drug therapy[MESH]|Sulfides[MESH]|Sulfonamides[MESH]|Tosyl Compounds/therapeutic use[MESH] |
