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lüll PGC-1 coactivators in cardiac development and disease Rowe GC; Jiang A; Arany ZCirc Res 2010[Oct]; 107 (7): 825-38The beating heart requires a constant flux of ATP to maintain contractile function, and there is increasing evidence that energetic defects contribute to the development of heart failure. The last 10 years have seen a resurgent interest in cardiac intermediary metabolism and a dramatic increase in our understanding of transcriptional networks that regulate cardiac energetics. The PPAR-gamma coactivator (PGC)-1 family of proteins plays a central role in these pathways. The mechanisms by which PGC-1 proteins regulate transcriptional networks and are regulated by physiological cues, as well as the roles they play in cardiac development and disease, are reviewed here.|Animals[MESH]|Carrier Proteins/metabolism[MESH]|Energy Metabolism/*physiology[MESH]|Heart Diseases/*metabolism[MESH]|Heart/*embryology[MESH]|Heat-Shock Proteins/*metabolism[MESH]|Humans[MESH]|Myocardium/*metabolism[MESH]|Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha[MESH]|RNA-Binding Proteins[MESH]|Transcription Factors/*metabolism[MESH] |