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lüll The thymus and the immune system: layered levels of control Lee DK; Hakim FT; Gress REJ Thorac Oncol 2010[Oct]; 5 (10 Suppl 4): S273-6Control points of normal thymopoiesis may provide insights into strategies for interrupting cell interactions in thymomas which appear to maintain active T cell production. Thymus production of T cells represents one of two pathways by which peripheral T cell populations are maintained or, if lost, regenerated. The production of T cells by the thymus results from a series of thymus epithelial cell (TEC) - thymocyte interactions from entry of thymocyte precursors into the thymus to release of mature naive single positive T cells into the periphery. Within this series of interactions, certain control points have been identified, all of which act through TEC to modulate thymopoiesis.|Animals[MESH]|Humans[MESH]|Immune System/physiology[MESH]|T-Lymphocytes/cytology/*immunology[MESH]|Thymoma/*immunology/pathology[MESH]|Thymus Gland/cytology/*immunology[MESH] |