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PALB2/FANCN: recombining cancer and Fanconi anemia Tischkowitz M; Xia BCancer Res 2010[Oct]; 70 (19): 7353-9Partner and localizer of BRCA2 (PALB2) was originally identified as a BRCA2-interacting protein that is crucial for key BRCA2 genome caretaker functions. It subsequently became clear that PALB2 was another Fanconi anemia (FA) gene (FANCN), and that monoallelic PALB2 mutations are associated with increased risk of breast and pancreatic cancer. Mutations in PALB2 have been identified in breast cancer families worldwide, and recent studies have shown that PALB2 also interacts with BRCA1. Here, we summarize the molecular functions and clinical phenotypes of this key DNA repair pathway component and discuss how its discovery has advanced our knowledge of both FA and adult cancer predisposition.|Animals[MESH]|Fanconi Anemia Complementation Group N Protein[MESH]|Fanconi Anemia/*genetics[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Neoplasms/*genetics[MESH]|Nuclear Proteins/*genetics[MESH]|Tumor Suppressor Proteins/*genetics[MESH] |