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lüll Stimulus-secretion coupling by high-affinity IgE receptor: new developments Benhamou M; Blank UFEBS Lett 2010[Dec]; 584 (24): 4941-8Stimulation of mast cells through their high affinity IgE receptor (FcepsilonRI) leads to the secretion of pre- and neoformed soluble mediators through vesicular carriers. This process is highly regulated in order to adapt the secretion of these potentially dangerous factors to the physiological needs. This regulation requires numerous essential effectors that are necessary to transmit the initial signal of FcepsilonRI aggregation and couple it to the sophisticated secretory machinery of membrane fusion. Studies in recent years have led to the discovery of a series of new effector molecules that link FcepsilonRI to secretion. We describe here some of the new developments that have allowed to obtain a clearer picture of stimulus/secretion coupling in mast cells.|Humans[MESH]|Mast Cells/enzymology/metabolism[MESH]|Membrane Fusion[MESH]|Phospholipid Transfer Proteins/metabolism[MESH]|Receptors, IgE/*metabolism[MESH]|SNARE Proteins/metabolism[MESH]|Signal Transduction[MESH] |