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lüll Allele-specific and heritable chromatin signatures in humans Birney E; Lieb JD; Furey TS; Crawford GE; Iyer VRHum Mol Genet 2010[Oct]; 19 (R2): R204-9Next-generation sequencing-based assays to detect gene regulatory elements are enabling the analysis of individual-to-individual and allele-specific variation of chromatin status and transcription factor binding in humans. Recently, a number of studies have explored this area, using lymphoblastoid cell lines. Around 10% of chromatin sites show either individual-level differences or allele-specific behavior. Future studies are likely to be limited by cell line accessibility, meaning that white-bloodcell-based studies are likely to continue to be the main source of samples. A detailed understanding of the relationship between normal genetic variation and chromatin variation can shed light on how polymorphisms in non-coding regions in the human genome might underlie phenotypic variation and disease.|*Alleles[MESH]|Chromatin/*genetics[MESH]|Genome, Human/*genetics[MESH]|Humans[MESH] |