Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Myofibroblast stromal presence and distribution in squamous epithelial carcinomas, oral dysplasia and hyperkeratosis Seifi S; Shafaei S; Shafigh E; Sahabi SM; Ghasemi HAsian Pac J Cancer Prev 2010[]; 11 (2): 359-64PURPOSE: Stromal elements play a key role in growth and development of different neoplasms. Myofibroblasts are the major components and occur in stromal tissue during carcinogenesis processes. The purpose of this study was to review the frequency and the distribution pattern of myofibroblasts(alphaSMA-positive) in the stroma of squamous epithelial carcinoma and to compare values with those for with oral dysplasia and hyperkeratosis. METHODS: we evaluated alphaSMA protein frequency in hyperkeratosis (N =18), oral epithelial dysplasia (N=18) and oral squamous cell carcinoma (N=18) using immunohistochemistry. RESULTS: alphaSMA-positive expression was observed in 67% of OSCC tissue samples with network and spindle patterns, whereas it was seen in 22% with a focal pattern in dysplasia and in 6% with a scanty pattern in hyperkeratosis cases. CONCLUSION: These findings suggest that an increase in number of myofibroblasts and change in their distribution pattern occurs during carcinogenesis which can be an expression of their role in tumor invasive characteristics.|Actins/*metabolism[MESH]|Adult[MESH]|Carcinoma, Squamous Cell/metabolism/*pathology[MESH]|Cross-Sectional Studies[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Humans[MESH]|Immunoenzyme Techniques[MESH]|Keratosis/metabolism/*pathology[MESH]|Male[MESH]|Middle Aged[MESH]|Mouth Neoplasms/metabolism/*pathology[MESH]|Muscle, Smooth/metabolism[MESH]|Myofibroblasts/metabolism/*pathology[MESH]|Precancerous Conditions/metabolism/*pathology[MESH]|Prognosis[MESH]|Stromal Cells/metabolism/*pathology[MESH]|Survival Rate[MESH] |
