Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Mechanisms of control of microRNA biogenesis Davis-Dusenbery BN; Hata AJ Biochem 2010[Oct]; 148 (4): 381-92MicroRNAs (miRNAs) are a class of approximately 22 nt non-coding RNAs that control diverse biological functions in animals, plants and unicellular eukaryotes by promoting degradation or inhibition of translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated. Aberrant expression of miRNAs has been linked to developmental abnormalities and human diseases, including cancer and cardiovascular disorders. The recent identification of mechanisms of miRNA biogenesis regulation uncovers that various factors or growth factor signalling pathways control every step of the miRNA biogenesis pathway. Here, we review the mechanisms that control the regulation of miRNA biogenesis discovered in human cells. Further understanding of the mechanisms that control of miRNA biogenesis may allow the development of tools to modulate the expression of specific miRNAs, which is crucial for the development of novel therapies for human disorders derived from aberrant expression of miRNAs.|DEAD-box RNA Helicases/metabolism[MESH]|Epigenesis, Genetic[MESH]|Eukaryotic Initiation Factors/metabolism[MESH]|HeLa Cells[MESH]|Humans[MESH]|MicroRNAs/*biosynthesis/genetics[MESH]|Nucleic Acid Conformation[MESH]|Proteins/metabolism[MESH]|RNA Interference[MESH]|RNA-Binding Proteins[MESH]|Ribonuclease III/metabolism[MESH]|Transcription, Genetic[MESH] |