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The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics Liu J; Wennier S; McFadden GMicrobes Infect 2010[Dec]; 12 (14-15): 1144-52Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an oncolytic agent in humans.|Animals[MESH]|Humans[MESH]|Immunologic Factors/*metabolism/therapeutic use[MESH]|Immunotherapy/methods[MESH]|Myxoma virus/*immunology[MESH]|Oncolytic Viruses/*immunology[MESH]|Rabbits[MESH]|Viral Proteins/*metabolism/therapeutic use[MESH] |
