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Virologic and immunologic response to HAART, by age and regimen class Althoff KN; Justice AC; Gange SJ; Deeks SG; Saag MS; Silverberg MJ; Gill MJ; Lau B; Napravnik S; Tedaldi E; Klein MB; Gebo KAAIDS 2010[Oct]; 24 (16): 2469-79OBJECTIVE: To determine the impact of age and initial HAART regimen class on virologic and immunologic response within 24 months after initiation. DESIGN: Pooled analysis of data from 19 prospective cohort studies in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). METHODS: Twelve thousand, one hundred and ninety-six antiretroviral-naive adults who initiated HAART between 1998 and 2008 using a boosted protease inhibitor-based regimen or a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimen were included in our study. Discrete time-to-event models estimated adjusted hazard odds ratios (aHOR) and 95% confidence intervals (CIs) for suppressed viral load (/=60: aHOR = 0.74 (0.65, 0.85)], regardless of initial regimen. CONCLUSION: We found no evidence of an interaction between age and initial antiretroviral regimen on virologic or immunologic response to HAART; however, decreased immunologic response with increasing age may have implications for age-specific when-to-start guidelines.|*Antiretroviral Therapy, Highly Active[MESH]|*HIV-1[MESH]|Adolescent[MESH]|Adult[MESH]|Age Distribution[MESH]|CD4 Lymphocyte Count[MESH]|Female[MESH]|HIV Infections/*drug therapy/immunology/virology[MESH]|Humans[MESH]|Logistic Models[MESH]|Male[MESH]|Middle Aged[MESH]|RNA, Viral/*immunology[MESH]|Viral Load[MESH]|Young Adult[MESH] |
