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lüll Cytoskeletal cross-talk in the control of T cell antigen receptor signaling Lasserre R; Alcover AFEBS Lett 2010[Dec]; 584 (24): 4845-50T cell antigen receptor signaling is triggered and controlled in specialized cellular interfaces formed between T cells and antigen-presenting cells named immunological synapses. Both microtubules and actin cytoskeleton rearrange at the immunological synapse in response to T cell receptor triggering, ensuring in turn the accuracy of intracellular signaling. Recent reports show that the cross-talk between the cortical actin cytoskeleton and microtubule networks is key for structuring the immunological synapse and for controlling T cell receptor signaling. Immunological synapse architecture and the interaction between the signaling machinery and various cytoskeletal elements are therefore crucial for the fine-tuning of T cell signaling.|*Signal Transduction[MESH]|Animals[MESH]|Cytoskeleton/*metabolism[MESH]|Humans[MESH]|Receptors, Antigen, T-Cell/*metabolism[MESH] |