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lüll A look at autoimmunity and inflammation in the eye Caspi RRJ Clin Invest 2010[Sep]; 120 (9): 3073-83Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular inflammatory diseases that arise without a known infectious trigger and are often associated with immunological responses to unique retinal proteins. In the United States, about 10% of the cases of severe visual handicap are attributed to this group of disorders. As I discuss here, experimental models of ocular autoimmunity targeting retinal proteins have brought about a better understanding of the basic immunological mechanisms involved in the pathogenesis of uveitis and are serving as templates for the development of novel therapies.|Animals[MESH]|Autoimmunity/*immunology[MESH]|Disease Models, Animal[MESH]|Eye/anatomy & histology/*immunology/pathology[MESH]|Forecasting[MESH]|Humans[MESH]|Inflammation/*immunology[MESH]|Macaca fascicularis[MESH]|Macaca mulatta[MESH]|Mice[MESH]|Mice, Nude[MESH]|Mice, Transgenic[MESH]|Rats[MESH]|Rats, Inbred Lew[MESH]|Retina/immunology/pathology[MESH]|Uveitis/immunology/pathology[MESH] |