Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life Sapieha P; Joyal JS; Rivera JC; Kermorvant-Duchemin E; Sennlaub F; Hardy P; Lachapelle P; Chemtob SJ Clin Invest 2010[Sep]; 120 (9): 3022-32Retinopathy of prematurity (ROP) is a major complication of preterm birth. It encompasses a spectrum of pathologies that affect vision, from mild disease that resolves spontaneously to severe disease that causes retinal detachment and subsequent blindness. The pathologies are characterized by an arrest in normal retinal vascular development associated with microvascular degeneration. The resulting ischemia and retinal hypoxia lead to excessive abnormal compensatory blood vessel growth. However, this neovascularization can lead to fibrous scar formation and culminate in retinal detachment. Present therapeutic modalities to limit the adverse consequences of aberrant neovascularization are invasive and/or tissue-destructive. In this Review, we discuss current concepts on retinal microvascular degeneration, neovascularization, and available treatments, as well as present future perspectives toward more profound elucidation of the pathogenesis of ROP.|Blindness/complications[MESH]|Blood Vessels/pathology[MESH]|Humans[MESH]|Infant, Newborn[MESH]|Infant, Premature[MESH]|Ischemia/complications[MESH]|Neovascularization, Pathologic/*complications/therapy[MESH]|Oxygen/toxicity[MESH]|Retinal Degeneration/complications[MESH]|Retinal Detachment/complications[MESH]|Retinal Diseases/*complications[MESH]|Retinopathy of Prematurity/*etiology/pathology/prevention & control[MESH] |
