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lüll Cerebral cavernous malformations as a disease of vascular permeability: from bench to bedside with caution Yadla S; Jabbour PM; Shenkar R; Shi C; Campbell PG; Awad IANeurosurg Focus 2010[Sep]; 29 (3): E4Tremendous insight into the molecular and genetic pathogenesis of cerebral cavernous malformations (CCMs) has been gained over the past 2 decades. This includes the identification of 3 distinct genes involved in familial CCMs. Still, a number of unanswered questions regarding the process from gene mutation to vascular malformation remain. It is becoming more evident that the disruption of interendothelial junctions and ensuing vascular hyperpermeability play a principal role. The purpose of this review is to summarize the current understanding of CCM genes, associated proteins, and functional pathways. Promising molecular and genetic therapies targeted at identified molecular aberrations are discussed as well.|Apoptosis Regulatory Proteins/genetics[MESH]|Capillary Permeability/genetics/*physiology[MESH]|Carrier Proteins/genetics[MESH]|Endothelium, Vascular/physiopathology[MESH]|Hemangioma, Cavernous, Central Nervous System/genetics/*physiopathology[MESH]|Humans[MESH]|Intercellular Junctions/genetics/physiology[MESH]|Intracranial Arteriovenous Malformations/metabolism/physiopathology[MESH]|KRIT1 Protein[MESH]|Membrane Proteins/genetics[MESH]|Microtubule-Associated Proteins/genetics[MESH]|Mutation/genetics/physiology[MESH]|Neovascularization, Pathologic/genetics/metabolism/physiopathology[MESH]|Proto-Oncogene Proteins/genetics[MESH] |