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  • CRLF2 and JAK2 in B-progenitor acute lymphoblastic leukemia: a novel association in oncogenesis
  • Roll JD; Reuther GW
  • Cancer Res 2010[Oct]; 70 (19): 7347-52
  • Expression of cytokine receptor-like factor 2 (CRLF2) has recently been shown to be upregulated as well as mutated in populations of B-progenitor acute lymphoblastic leukemia (B-ALL), including Down syndrome (DS-ALL) patients, lacking recurring chromosomal translocations. Increased CRLF2 expression associates with JAK2 mutation, a combination that transforms hematopoietic cells, suggesting that mutant JAK2 and CRLF2 may cooperate to contribute to B-ALL formation. Importantly, elevated CRLF2 expression correlates with poor outcome in high-risk B-ALL patients. Therefore, CRLF2 may provide a new prognostic marker for high-risk B-ALL, and inhibition of CRLF2/JAK2 signaling may represent a therapeutic approach for this population of ALL patients.
  • |Animals[MESH]
  • |Humans[MESH]
  • |Janus Kinase 2/*genetics[MESH]
  • |Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics[MESH]
  • |Receptors, Cytokine/*genetics[MESH]





  • *{{pmid20807819}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=20807819 CRLF2 and JAK2 in B-progenitor acute lymphoblastic leukemia: a novel association in oncogenesis ]</b> Cancer Res 2010; 70(19) ; 7347-52 Roll JD; Reuther GW

        *20807819*

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    Cancer Res

    7347 19.70 2010