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Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity Amano M; Nakayama M; Kaibuchi KCytoskeleton (Hoboken) 2010[Sep]; 67 (9): 545-54Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological analyses have revealed that Rho-kinase is involved in a wide range of diseases such as vasospasm, pulmonary hypertension, nerve injury, and glaucoma, and is therefore considered to be a potential therapeutic target. This review focuses on the structure, function, and modes of activation and action of Rho-kinase.|*rho-Associated Kinases/chemistry/physiology[MESH]|Actins/physiology[MESH]|Cell Movement/genetics[MESH]|Cell Polarity/*genetics[MESH]|Crystallography, X-Ray[MESH]|Cytokinesis/physiology[MESH]|Cytoskeleton/*physiology[MESH]|Enzyme Activation[MESH]|Muscle Contraction/physiology[MESH]|Neurites/physiology[MESH]|rho GTP-Binding Proteins/metabolism[MESH] |
