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Muscle atrophy in chronic kidney disease results from abnormalities in insulin signaling Price SR; Gooch JL; Donaldson SK; Roberts-Wilson TKJ Ren Nutr 2010[Sep]; 20 (5 Suppl): S24-8Muscle atrophy is a significant consequence of chronic kidney disease that increases a patient's risk of mortality and decreases their quality of life. The loss of lean body mass results, in part, from an increase in the rate of muscle protein degradation. In this review, the proteolytic systems that are activated during chronic kidney disease and the key insulin signaling pathways that regulate the protein degradative processes are described.|*Signal Transduction[MESH]|Acidosis/complications[MESH]|Animals[MESH]|Chronic Disease[MESH]|Glucocorticoids/biosynthesis[MESH]|Humans[MESH]|Insulin Resistance[MESH]|Insulin-Like Growth Factor I/metabolism[MESH]|Insulin/*physiology[MESH]|Kidney Diseases/*complications[MESH]|Muscle Proteins/metabolism[MESH]|Muscular Atrophy/*etiology[MESH]|Peptide Hydrolases/metabolism[MESH]|Phosphatidylinositol 3-Kinases/metabolism[MESH]|Proto-Oncogene Proteins c-akt/metabolism[MESH] |
