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Arrhythmia and right heart disease: from genetic basis to clinical practice Capulzini L; Brugada P; Brugada J; Brugada RRev Esp Cardiol 2010[Aug]; 63 (8): 963-83Historically, left ventricular cardiomyopathy and coronary heart disease have been regarded as the main causes of ventricular arrhythmia and sudden cardiac death. However, within last two decades, arrhythmias originating from the right ventricle have begun to attract the attention of the scientific world for a number of reasons. Ventricular arrhythmias originating from the right ventricle usually affect younger patients and can lead to sudden cardiac death. The pathophysiologic mechanism of these arrhythmias is not fully understood, which can leave room for a range of different interpretations. Moreover, the intriguing world of genetics is increasingly being drawn into the pathogenesis, diagnosis and prognosis of some of these arrhythmias. This review considers the pathogenesis, diagnosis and treatment of arrhythmogenic right ventricular cardiomyopathy or dysplasia (ARVD), Brugada syndrome, right ventricular outflow tract ventricular tachycardia, and arrhythmias in the right side of the heart due to congenital heart disease. In addition, because ventricular arrhythmias associated with right ventricular heart diseases such as Brugada syndrome and ARVD can explain up to 10-30% of sudden cardiac deaths in young adults in the general population and an even greater percentage in young athletes, this article contains a brief analysis of screening tests used before participation in sports, life-style modification, and treatment options for athletes affected by these conduction disorders.|Arrhythmias, Cardiac/diagnosis/*etiology/genetics/therapy[MESH]|Arrhythmogenic Right Ventricular Dysplasia/diagnosis/etiology/genetics/therapy[MESH]|Brugada Syndrome/diagnosis/etiology/genetics/therapy[MESH]|Humans[MESH]|Ventricular Outflow Obstruction/complications[MESH] |
