Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Complement-dependent transport of antigen into B cell follicles Gonzalez SF; Lukacs-Kornek V; Kuligowski MP; Pitcher LA; Degn SE; Turley SJ; Carroll MCJ Immunol 2010[Sep]; 185 (5): 2659-64Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes.|Animals[MESH]|Antigens/*metabolism[MESH]|B-Lymphocyte Subsets/*immunology/*metabolism/virology[MESH]|Cell Compartmentation/immunology[MESH]|Complement System Proteins/*physiology[MESH]|Dendritic Cells/immunology/metabolism/virology[MESH]|Humans[MESH]|Lymphoid Tissue/cytology/*immunology/*metabolism[MESH]|Protein Transport/immunology[MESH] |