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lüll Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols Yang CS; Lu G; Ju J; Li GXAnn N Y Acad Sci 2010[Aug]; 1203 (ä): 29-34Tocopherols, which exist in alpha, beta, gamma, and delta forms, are antioxidative nutrients also known as vitamin E. Although alpha-tocopherol (alpha-T) is the major form of vitamin E found in the blood and tissues, gamma- and delta-T have been suggested to have stronger anti-inflammatory activities. In the present study, using a tocopherol mixture that is rich in gamma-T (gamma-TmT, which contains 57%gamma-T), we demonstrated the inhibition of inflammation as well as of cancer formation and growth in the lung and colon in animal models. When given in the diet at 0.3%, gamma-TmT inhibited chemically induced lung tumorigenesis in the A/J mice as well as the growth of human lung cancer cell H1299 xenograft tumors. gamma-TmT also decreased the levels of 8-hydroxydeoxyguanosine, gamma-H2AX, and nitrotyrosine in tumors. More evident anti-inflammatory and cancer preventive activities of dietary gamma-TmT were demonstrated in mice treated with azoxymethane and dextran sulfate sodium. These results demonstrate the antioxidative, anti-inflammatory, and anticarcinogenic activities of tocopherols.|Animals[MESH]|Antineoplastic Agents/*pharmacology/therapeutic use[MESH]|Antioxidants/pharmacology/therapeutic use[MESH]|Cell Transformation, Neoplastic/*metabolism/pathology[MESH]|Colonic Neoplasms/metabolism/*pathology/*prevention & control[MESH]|Humans[MESH]|Inflammation Mediators/antagonists & inhibitors/*physiology/therapeutic use[MESH]|Lung Neoplasms/metabolism/*pathology/*prevention & control[MESH]|Tocopherols/*pharmacology/therapeutic use[MESH] |