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lüll Mitochondria and aging in the vascular system Ungvari Z; Sonntag WE; Csiszar AJ Mol Med (Berl) 2010[Oct]; 88 (10): 1021-7This review focuses on mitochondrial abnormalities that occur in the vasculature during aging and explores the link between mitochondrial oxidative stress, chronic low-grade vascular inflammation, increased rate of endothelial apoptosis, and development of vascular diseases in the elderly. Therapeutic strategies targeting the mitochondria for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the vasoprotective effects of caloric restriction, caloric restriction mimetics, the GH/IGF-1 axis, and mitochondria-targeted antioxidants.|Aging/*physiology[MESH]|Blood Vessels/*metabolism[MESH]|Endothelium/metabolism[MESH]|Humans[MESH]|Inflammation/metabolism[MESH]|Mitochondria/*metabolism[MESH]|Oxidative Stress[MESH]|Reactive Oxygen Species/metabolism[MESH]|Vascular Diseases/metabolism[MESH] |