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lüll Multiple beneficial health effects of natural alkylglycerols from shark liver oil Deniau AL; Mosset P; Pedrono F; Mitre R; Le Bot D; Legrand ABMar Drugs 2010[Jul]; 8 (7): 2175-84Alkylglycerols (alkyl-Gro) are ether lipids abundant in the liver of some elasmobranch fish species such as ratfishes and some sharks. Shark liver oil from Centrophorus squamosus (SLO), or alkyl-Gro mix from this source, have several in vivo biological activities including stimulation of hematopoiesis and immunological defences, sperm quality improvement, or anti-tumor and anti-metastasis activities. Several mechanisms are suggested for these multiple activities, resulting from incorporation of alkyl-Gro into membrane phospholipids, and lipid signaling interactions. Natural alkyl-Gro mix from SLO contains several alkyl-Gro, varying by chain length and unsaturation. Six prominent constituents of natural alkyl-Gro mix, namely 12:0, 14:0, 16:0, 18:0, 16:1 n-7, and 18:1 n-9 alkyl-Gro, were synthesized and tested for anti-tumor and anti-metastatic activities on a model of grafted tumor in mice (3LL cells). 16:1 and 18:1 alkyl-Gro showed strong activity in reducing lung metastasis number, while saturated alkyl- Gro had weaker (16:0) or no (12:0, 14:0, 18:0) effect. Multiple compounds and mechanisms are probably involved in the multiple activities of natural alkyl-Gro.|Animals[MESH]|Antineoplastic Agents/chemistry/*pharmacology[MESH]|Drug Screening Assays, Antitumor[MESH]|Fish Oils/chemistry/*pharmacology[MESH]|Glycerol/chemistry/*pharmacology[MESH]|Humans[MESH]|Mice[MESH]|Neoplasm Metastasis[MESH]|Neoplasms/drug therapy/pathology[MESH]|Sharks[MESH] |