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lüll The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?Brabletz S; Brabletz TEMBO Rep 2010[Sep]; 11 (9): 670-7Epithelial-to-mesenchymal transition (EMT) is a fundamental process in development and disease. Zinc-finger enhancer binding (ZEB) transcription factors (ZEB1 and ZEB2) are crucial EMT activators, whereas members of the miR-200 family induce epithelial differentiation. They are reciprocally linked in a feedback loop, each strictly controlling the expression of the other. Now data show that EMT not only confers cellular motility, but also induces stem-cell properties and prevents apoptosis and senescence. Thus the balanced expression of ZEB factors and miR-200 controls all these processes. We therefore propose that the ZEB/miR-200 feedback loop is the molecular motor of cellular plasticity in development and disease, and in particular is a driving force for cancer progression towards metastasis by controlling the state of cancer stem cells.|*Feedback, Physiological[MESH]|Apoptosis[MESH]|Cell Differentiation[MESH]|Cell Proliferation[MESH]|Cellular Senescence[MESH]|Epithelial-Mesenchymal Transition/physiology[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Homeodomain Proteins/*metabolism[MESH]|Humans[MESH]|MicroRNAs/genetics/*metabolism[MESH]|Neoplasms/*physiopathology[MESH]|Repressor Proteins/*metabolism[MESH]|Transcription Factors/*metabolism[MESH]|Zinc Finger E-box Binding Homeobox 2[MESH]|Zinc Finger E-box-Binding Homeobox 1[MESH] |