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lüll Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information Zaidi SK; Young DW; Montecino M; Lian JB; Stein JL; van Wijnen AJ; Stein GSMol Cell Biol 2010[Oct]; 30 (20): 4758-66Epigenetic regulatory information must be retained during mammalian cell division to sustain phenotype-specific and physiologically responsive gene expression in the progeny cells. Histone modifications, DNA methylation, and RNA-mediated silencing are well-defined epigenetic mechanisms that control the cellular phenotype by regulating gene expression. Recent results suggest that the mitotic retention of nuclease hypersensitivity, selective histone marks, as well as the lineage-specific transcription factor occupancy of promoter elements contribute to the epigenetic control of sustained cellular identity in progeny cells. We propose that these mitotic epigenetic signatures collectively constitute architectural epigenetics, a novel and essential mechanism that conveys regulatory information to sustain the control of phenotype and proliferation in progeny cells by bookmarking genes for activation or suppression.|*Epigenesis, Genetic[MESH]|Adenosine Triphosphatases/metabolism[MESH]|Animals[MESH]|Cell Differentiation[MESH]|Cell Proliferation[MESH]|DNA Methylation[MESH]|DNA-Binding Proteins/metabolism[MESH]|Gene Expression Regulation[MESH]|Histones/metabolism[MESH]|Humans[MESH]|Mammals/*genetics/metabolism[MESH]|Mitosis/genetics[MESH]|Models, Genetic[MESH]|Multiprotein Complexes/metabolism[MESH]|Phenotype[MESH]|Protein Processing, Post-Translational[MESH]|RNA, Untranslated/genetics[MESH]|Transcription Factors/metabolism[MESH] |