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lüll Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation Jager A; Kuchroo VKScand J Immunol 2010[Sep]; 72 (3): 173-84Many autoimmune diseases are driven by self-reactive T helper cells. Until recently, organ-specific autoimmune diseases were primarily associated with Th1 cells but not Th2 cells. However, the discovery of a number of new effector T-cell subsets, like Th17 and Th9 cells, and regulatory T cells, like Tregs and Tr1 cells, has changed the way we view and understand autoimmunity at cellular and molecular levels. In recent years, IL-17-producing Th17 cells have emerged as major players in autoimmunity. The complicated relationship between Th1 and Th17 cells, as well as the intricate balance between Tregs and Th17 cells, provides a basis for understanding the immunological mechanisms that induce and regulate autoimmunity. Here, we give an overview of the interplay between different effector T-cell subsets and regulatory T-cell subsets, and how they contribute to the development of autoimmunity and tissue inflammation.|Animals[MESH]|Autoimmunity/*immunology[MESH]|Humans[MESH]|Inflammation/*immunology[MESH]|T-Lymphocytes, Helper-Inducer/cytology/*immunology/metabolism[MESH]|T-Lymphocytes, Regulatory/cytology/*immunology/metabolism[MESH] |