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lüll Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation Jager A; Kuchroo VK Scand J Immunol 2010[Sep]; 72 (3): 173-84 Many autoimmune diseases are driven by self-reactive T helper cells. Until recently, organ-specific autoimmune diseases were primarily associated with Th1 cells but not Th2 cells. However, the discovery of a number of new effector T-cell subsets, like Th17 and Th9 cells, and regulatory T cells, like Tregs and Tr1 cells, has changed the way we view and understand autoimmunity at cellular and molecular levels. In recent years, IL-17-producing Th17 cells have emerged as major players in autoimmunity. The complicated relationship between Th1 and Th17 cells, as well as the intricate balance between Tregs and Th17 cells, provides a basis for understanding the immunological mechanisms that induce and regulate autoimmunity. Here, we give an overview of the interplay between different effector T-cell subsets and regulatory T-cell subsets, and how they contribute to the development of autoimmunity and tissue inflammation. |Animals[MESH] |Autoimmunity/*immunology[MESH] |Humans[MESH] |Inflammation/*immunology[MESH] |T-Lymphocytes, Helper-Inducer/cytology/*immunology/metabolism[MESH] |T-Lymphocytes, Regulatory/cytology/*immunology/metabolism[MESH]

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*<b>[http://www.kidney.de/mlpefetch.php?search=20696013 Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation ]</b> Scand J Immunol 2010; 72(3) ; 173-84 Jager A; Kuchroo VK

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{{recpmid|pmid=20696013|ti=Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation |au=Jager A; Kuchroo VK|so=Scand J Immunol 2010; 72 (3): 173-84|ab=Many autoimmune diseases are driven by self-reactive T helper cells. Until recently, organ-specific autoimmune diseases were primarily associated with Th1 cells but not Th2 cells. However, the discovery of a number of new effector T-cell subsets, like Th17 and Th9 cells, and regulatory T cells, like Tregs and Tr1 cells, has changed the way we view and understand autoimmunity at cellular and molecular levels. In recent years, IL-17-producing Th17 cells have emerged as major players in autoimmunity. The complicated relationship between Th1 and Th17 cells, as well as the intricate balance between Tregs and Th17 cells, provides a basis for understanding the immunological mechanisms that induce and regulate autoimmunity. Here, we give an overview of the interplay between different effector T-cell subsets and regulatory T-cell subsets, and how they contribute to the development of autoimmunity and tissue inflammation.}}
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{{BibRecord | Autor = Jager A; Kuchroo VK | Titel = Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation | Band = 72 | Nummer = 3 | Jahr = 2010 | Monat = Sep | Sprache = eng | DOI = | Seite = 173-84 | PMID = 20696013 | Typ= {{{Typ|}}} | Kommentar = {{{Kommentar|}}} | format = {{{format|}}} | record = {{{record|}}} }}

Scand J Immunol