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lüll Artificial antigen-presenting cells for use in adoptive immunotherapy Turtle CJ; Riddell SRCancer J 2010[Jul]; 16 (4): 374-81The observation that T cells can recognize and specifically eliminate cancer cells has spurred interest in the development of efficient methods to generate large numbers of T cells with specificity for tumor antigens that can be harnessed for use in cancer therapy. Recent studies have demonstrated that during encounter with tumor antigen, the signals delivered to T cells by professional antigen-presenting cells can affect T-cell programming and their subsequent therapeutic efficacy. This has stimulated efforts to develop artificial antigen-presenting cells that allow optimal control over the signals provided to T cells. In this review, we will discuss the advantages and disadvantages of cellular and acellular artificial antigen-presenting cell systems and their use in T-cell adoptive immunotherapy for cancer.|Animals[MESH]|Antigen Presentation[MESH]|Antigen-Presenting Cells/*immunology[MESH]|Artificial Cells/*immunology[MESH]|Cell Line, Tumor[MESH]|Humans[MESH]|Immunotherapy, Adoptive/*methods[MESH]|Neoplasms/*immunology/*therapy[MESH] |