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lüll Wnt/beta-catenin signaling in T-cell immunity and cancer immunotherapy Gattinoni L; Ji Y; Restifo NPClin Cancer Res 2010[Oct]; 16 (19): 4695-701Wnt ligands are lipid-modified secreted glycoproteins that regulate embryonic development, cell fate specification, and the homeostasis of self-renewing adult tissues. In addition to its well-established role in thymocyte development, recent studies have indicated that Wnt/beta-catenin signaling is critical for the differentiation, polarization, and survival of mature T lymphocytes. Here, we describe our current understanding of Wnt signaling in the biology of post-thymic T cells, and discuss how harnessing the Wnt/beta-catenin pathway might improve the efficacy of vaccines, T-cell-based therapies, and allogeneic stem cell transplantation for the treatment of patients with cancer.|*Immunotherapy[MESH]|Hematopoietic Stem Cell Transplantation[MESH]|Humans[MESH]|Immunity[MESH]|Neoplasms/immunology/*therapy[MESH]|Signal Transduction/*immunology[MESH]|T-Lymphocytes/*immunology[MESH]|Transplantation, Autologous[MESH]|Wnt Proteins/*immunology[MESH]|beta Catenin/*immunology[MESH] |