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Natalizumab (Tysabri) Selewski DT; Shah GV; Segal BM; Rajdev PA; Mukherji SKAJNR Am J Neuroradiol 2010[Oct]; 31 (9): 1588-90Natalizumab is a humanized IgG4kappa monoclonal antibody that is a selective adhesion molecule inhibitor, which prevents adhesion of leukocytes to endothelial cells. It is the first monoclonal antibody approved by the FDA for the treatment of relapsing-remitting MS. This article will review the mechanism of action and clinical role of this agent.|Animals[MESH]|Antibodies, Monoclonal, Humanized[MESH]|Antibodies, Monoclonal/*administration & dosage/*immunology[MESH]|Brain/drug effects/*immunology[MESH]|Cell Adhesion/drug effects/immunology[MESH]|Cell Migration Inhibition/drug effects/immunology[MESH]|Humans[MESH]|Leukocytes/drug effects/*immunology[MESH]|Models, Immunological[MESH]|Multiple Sclerosis/*drug therapy/*immunology[MESH]|Natalizumab[MESH] |
