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Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy Lu S; Wang YClin Cancer Res 2010[Aug]; 16 (15): 3822-4A sensitive and specific fluorescence resonance energy transfer (FRET) biosensor was developed by Mizutani and colleagues and applied to detect the activity of BCR-ABL kinase in live cells. This biosensor allowed the detection of cancerous and drug-resistant cells, and the evaluation of kinase inhibitor efficacy. Future biosensor development and imaging can increasingly contribute to cancer diagnosis and therapeutics.|Animals[MESH]|Biomarkers, Tumor/*analysis[MESH]|Biosensing Techniques/*methods[MESH]|Drug Resistance, Neoplasm[MESH]|Fluorescence Resonance Energy Transfer/*methods[MESH]|Humans[MESH]|Neoplasms/*diagnosis/drug therapy[MESH] |
