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Genetics of systemic lupus erythematosus: contributions of mouse models in the era of human genome-wide association studies Xu Z; Morel LDiscov Med 2010[Jul]; 10 (50): 71-8The past two years have brought great progress in the genetics of systemic lupus erythematosus (SLE) heralded by the publication of genome-wide association studies in humans and the identification of susceptibility genes in mouse models of spontaneous lupus. This influx of new information has revealed an ever-increasing interdependence between the mouse and human systems for unraveling the genetic basis of lupus susceptibility. SLE is a complex disease in which defects in several functional pathways have been identified. Genetic variants in a number of genes in these pathways have now been directly associated with lupus in both species. These discoveries have lead to a better understanding of the mechanisms of disease, and offer potential novel target for therapeutic intervention. As a large number of susceptibility genes are identified, lupus genetics will focus on mechanistic and molecular studies, in which mouse models will continue to serve a pre-eminent role.|*Disease Models, Animal[MESH]|*Genome-Wide Association Study[MESH]|Animals[MESH]|Genetic Loci/genetics[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Lupus Erythematosus, Systemic/*genetics[MESH]|Mice[MESH] |
