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Celiac disease: evaluation with dynamic contrast-enhanced MR imaging Masselli G; Picarelli A; Di Tola M; Libanori V; Donato G; Polettini E; Piermattei A; Palumbo P; Pittalis A; Saponara A; Gualdi GRadiology 2010[Sep]; 256 (3): 783-90PURPOSE: To prospectively determine mural perfusion dynamics in patients with untreated celiac disease by using dynamic contrast material-enhanced magnetic resonance (MR) imaging and to compare these dynamics with those in a control population and in patients with celiac disease treated with a gluten-free diet. MATERIALS AND METHODS: Institutional review board approval and informed consent from all participants were obtained. Sixty consecutive patients with untreated celiac disease, 45 patients with celiac disease treated with a gluten-free diet for at least 1 year, and 30 control subjects were enrolled in this study. Dynamic contrast-enhanced MR imaging was performed by using a 1.5-T MR unit. For each MR imaging examination, maximum enhancement, slope of enhancement, and time-signal intensity curves were calculated at the level of the descending duodenal wall. Duodenal wall thickness was also evaluated. Statistical evaluation was performed by using one-way analysis of variance, and the results were confirmed by using the Bartlett test for equal variances and complemented by using Bonferroni multiple comparison, linear correlation, and the Student t test for paired data. RESULTS: Mean maximum enhancement of the duodenal wall was significantly higher in patients with untreated celiac disease (229.1 +/- 46.4 [standard deviation]) than in patients with treated celiac disease (109.8 +/- 27.8) and control subjects (94.7 +/- 17.9) (P < .001 for each comparison). All 60 untreated patients showed a curve characterized by fast enhancement and washout (type 4), while all 45 treated patients and the 30 control subjects showed a curve characterized by slow constant enhancement (type 2). Mean duodenal wall thickness was not significantly different between untreated patients (2.2 mm +/- 0.4), treated patients (2.0 mm +/- 0.3), and control subjects (2.0 mm +/- 0.4) (one-way analysis of variance, P = .4177; Bartlett test, P = .6951). CONCLUSION: The results of this study suggest that dynamic evaluation of the bowel wall by using contrast-enhanced MR imaging can be an effective and reproducible way to show the inflammation state in celiac disease.|Adolescent[MESH]|Adult[MESH]|Analysis of Variance[MESH]|Biopsy[MESH]|Celiac Disease/diet therapy/*pathology[MESH]|Contrast Media[MESH]|Diet, Gluten-Free[MESH]|Electrolytes[MESH]|Female[MESH]|Humans[MESH]|Image Enhancement/methods[MESH]|Image Interpretation, Computer-Assisted[MESH]|Imaging, Three-Dimensional[MESH]|Magnetic Resonance Imaging/*methods[MESH]|Male[MESH]|Meglumine[MESH]|Middle Aged[MESH]|Organometallic Compounds[MESH]|Polyethylene Glycols[MESH]|Prospective Studies[MESH]|Reproducibility of Results[MESH] |
