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lüll Topical endotracheal mitomycin C as a complementary treatment for endoscopic treatment of recurrent laryngotracheal stenosis Cortes de Miguel S; Cabeza Barrera J; Gallardo Medina M; Cassini Gomez de Cadiz LF; Salmeron-Garcia A; Rodriguez Lucas FFarm Hosp 2011[Jan]; 35 (1): 32-5OBJECTIVE: To describe the preparation of topical endotracheal mitomycin C and the clinical outcomes of four patients with recurrent and severe laryngotracheal stenosis (LTS) treated with adjuvant topical mitomycin C. METHOD: Literature review to determine the concentration and method of preparation of topical mitomycin C for endotracheal use. Review of clinical histories. RESULTS: We established a concentration of 0.4 mg/ml topical mitomycin C for the treatment of laryngotracheal stenosis. In the treated cases, we applied a 0.4 mg/ml solution to the wound site following laser surgery and dilatation with bronchoscope. Three patients remain asymptomatic from a respiratory perspective, and treatment failed in one case. CONCLUSIONS: LTS treatment is complex due to the continuous development of granulation tissue and fibrosis following injury to the airways. Topical mitomycin C seems to be the ideal adjuvant agent thanks to its powerful antifibrotic effects.|*Laryngoscopy[MESH]|Administration, Topical[MESH]|Adult[MESH]|Combined Modality Therapy[MESH]|Female[MESH]|Humans[MESH]|Laryngostenosis/complications/*therapy[MESH]|Male[MESH]|Middle Aged[MESH]|Mitomycin/*administration & dosage[MESH]|Recurrence[MESH]|Tracheal Stenosis/complications/*therapy[MESH]|Young Adult[MESH] |