Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Hydroxyurea in children with sickle cell disease: practice patterns and barriers to utilization Brandow AM; Jirovec DL; Panepinto JAAm J Hematol 2010[Aug]; 85 (8): 611-3Hydroxyurea (HU) is underutilized in adults with sickle cell disease (SCD) despite the Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH) (1). Since little is known about HU utilization in children with SCD we sought to: 1) evaluate patterns of HU utilization; 2) elicit how providers define frequent pain when prescribing HU; and 3) identify barriers to HU use by surveying members of the American Society of Pediatric Hematology/Oncology. Data analysis included descriptive statistics and Chi-square. Of the 350 respondents, 63% care for SCD patients. Of these providers, only 9% have 50-90% of patients on HU, while 10% have <10% on HU. Criteria used to initiate HU included acute chest syndrome and frequent pain. Approximately half of providers account only for pain requiring hospitalization when prescribing HU. Those accounting for pain managed at home were more likely to have >30% of patients on HU (35.2% vs. 20%; p=0.023; Chi-square). Provider-related barriers to prescribing HU included compliance with: HU (86%), laboratory monitoring (85%), and contraception (85%). Our survey suggests substantial variation in HU utilization in children. Providers accounting for pain managed both in and out of the hospital had more patients on HU. Existing barriers to HU utilization should be addressed to optimize care for children with SCD.|*Attitude of Health Personnel[MESH]|*Practice Patterns, Physicians'[MESH]|Anemia, Sickle Cell/complications/*drug therapy[MESH]|Child[MESH]|Contraception/statistics & numerical data[MESH]|Data Collection[MESH]|Drug Monitoring/statistics & numerical data[MESH]|Drug Utilization[MESH]|Female[MESH]|Guideline Adherence[MESH]|Hematology[MESH]|Hospitalization/statistics & numerical data[MESH]|Humans[MESH]|Hydroxyurea/adverse effects/*therapeutic use[MESH]|Male[MESH]|Medical Oncology[MESH]|Pain/etiology/prevention & control[MESH]|Patient Compliance/statistics & numerical data[MESH]|Pediatrics[MESH]|Physicians/psychology/statistics & numerical data[MESH] |