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lüll Cathepsins and their involvement in immune responses Conus S; Simon HUSwiss Med Wkly 2010[]; 140 (ä): w13042The immune system is composed of an enormous variety of cells and molecules that generate a collective and coordinated response on exposure to foreign antigens, called the immune response. Within the immune response, endo-lysosomal proteases play a key role. In this review we cover specific roles of cathepsins in innate and adaptive immunity, as well as their implication in the pathogenesis of several diseases.|Adaptive Immunity/*immunology[MESH]|Alzheimer Disease/immunology[MESH]|Animals[MESH]|Antigen-Presenting Cells/immunology[MESH]|Apoptosis/immunology[MESH]|Arthritis, Rheumatoid/immunology[MESH]|Asthma/immunology[MESH]|Atherosclerosis/immunology[MESH]|Cathepsins/*physiology[MESH]|Cytokines/physiology[MESH]|Granzymes/physiology[MESH]|Humans[MESH]|Immunity, Cellular/immunology[MESH]|Immunity, Innate/*immunology[MESH]|Immunocompetence/immunology[MESH]|Inflammation/immunology[MESH]|Lysosomes/immunology[MESH]|Mice[MESH]|Neoplasms/immunology[MESH]|Osteoarthritis/immunology[MESH]|Peptide Hydrolases/physiology[MESH] |