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Human non-CG methylation: are human stem cells plant-like?Dyachenko OV; Schevchuk TV; Kretzner L; Buryanov YI; Smith SSEpigenetics 2010[Oct]; 5 (7): 569-72Non-CG methylation is well characterized in plants, where it appears to play a role in gene silencing and genomic imprinting. Although strong evidence for the presence of non-CG methylation in animals has been available for some time, both its origin and function remain elusive. In this review we discuss available evidence on non-CG methylation in animals in light of evidence suggesting that the human stem cell methylome contains significant levels of methylation outside the CG site.|*DNA Methylation[MESH]|Animals[MESH]|Base Sequence[MESH]|Binding Sites/genetics[MESH]|DNA Modification Methylases/metabolism[MESH]|DNA, Plant/genetics/metabolism[MESH]|Humans[MESH]|Plants/*genetics/*metabolism[MESH]|Stem Cells/*metabolism[MESH] |
