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lüll Interferon-lambda in the immune response to hepatitis B virus and hepatitis C virus Pagliaccetti NE; Robek MDJ Interferon Cytokine Res 2010[Aug]; 30 (8): 585-90Approximately 500 million people worldwide are chronically infected with the hepatitis B virus (HBV) or hepatitis C virus (HCV), and are therefore at an increased risk for developing fatal liver diseases such as cirrhosis and hepatocellular carcinoma. The intracellular antiviral responses induced by interferon (IFN)-alpha/-beta and/or IFN-gamma play critical roles in the pathogenesis of HBV and HCV infection, and the function of IFN-lambda in the host immune response to these viruses is beginning to be revealed. A better understanding of how IFN-lambda influences HBV or HCV persistence is not only important for understanding the mechanisms of chronic virus infection, but also may lead to new approaches for improved antiviral therapies.|*Hepatitis B, Chronic/drug therapy/epidemiology/immunology[MESH]|*Hepatitis C, Chronic/drug therapy/epidemiology/immunology[MESH]|Animals[MESH]|Antiviral Agents/therapeutic use[MESH]|Carcinoma, Hepatocellular/*epidemiology[MESH]|Comorbidity[MESH]|Cytokines/*immunology/therapeutic use[MESH]|Hepacivirus/*immunology[MESH]|Hepatitis B virus/*immunology[MESH]|Humans[MESH]|Immunity, Innate[MESH]|Liver Cirrhosis/*epidemiology[MESH]|Mice[MESH]|Prevalence[MESH] |