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lüll Lung sarcoidosis induced by TNF antagonists in rheumatoid arthritis: a case presentation and a literature review Gifre L; Ruiz-Esquide V; Xaubet A; Gomez-Puerta JA; Hernandez MV; Sanmarti RArch Bronconeumol 2011[Apr]; 47 (4): 208-12We report on a 72 year-old woman with long-standing rheumatoid arthritis diagnosed as granulomatosis due to pulmonary sarcoidosis after 49 months of treatment with etanercept. A clinical and radiological improvement was seen after tumor necrosis factor (TNF) antagonist withdrawal plus a course of steroids. Currently, 27 cases of histological proven sarcoidosis with pulmonary involvement have been reported in relation to anti-TNF therapy, with etanercept being more frequent in comparison with the anti-TNF monoclonal antibodies infliximab and adalimumab. Potential pathogenic mechanisms of the paradoxical effect of anti-TNF treatment is discussed. It is important for clinicians to be aware of this potential and uncommon complication of biological therapy with TNF antagonists.|Aged[MESH]|Antirheumatic Agents/*adverse effects[MESH]|Arthritis, Rheumatoid/complications/*drug therapy[MESH]|Biopsy[MESH]|Etanercept[MESH]|Female[MESH]|Humans[MESH]|Immunoglobulin G/*adverse effects[MESH]|Prednisone/administration & dosage/therapeutic use[MESH]|Radiography[MESH]|Receptors, Tumor Necrosis Factor[MESH]|Sarcoidosis, Pulmonary/*chemically induced/diagnostic imaging/drug therapy/pathology[MESH] |