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Inflammasome inhibition as a pathogenic stealth mechanism Taxman DJ; Huang MT; Ting JPCell Host Microbe 2010[Jul]; 8 (1): 7-11The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host defense against microbial pathogens. Recent discoveries have uncovered a plethora of pathogenic strategies to inhibit inflammasome-mediated processing of IL-1beta and IL-18. We review recent evidence for viral and bacterial manipulation of the inflammasome, ranging from perturbation of caspase-1 activation to targeting of specific inflammasome components.|*Down-Regulation[MESH]|*Host-Pathogen Interactions[MESH]|Animals[MESH]|Bacteria/*immunology/pathogenicity[MESH]|Bacterial Infections/*immunology/microbiology[MESH]|Humans[MESH]|Virus Diseases/*immunology/virology[MESH]|Viruses/*immunology/pathogenicity[MESH] |
