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  • Molecular and cellular basis of T cell lineage commitment
  • Vicente R; Swainson L; Marty-Gres S; De Barros SC; Kinet S; Zimmermann VS; Taylor N
  • Semin Immunol 2010[Oct]; 22 (5): 270-5
  • The thymus forms as an alymphoid thymic primordium with T cell differentiation requiring the seeding of this anlage. This review will focus on the characteristics of the hematopoietic progenitors which colonize the thymus and their subsequent commitment/differentiation, both in mice and men. Within the thymus, the interplay between Notch1 and IL-7 signals is crucial for the orchestration of T cell development, but the precise requirements for these factors in murine and human thympoeisis are not synonymous. Recent advances in our understanding of the mechanisms regulating precursor entry and their maintenance in the thymus will also be presented.
  • |*Cell Lineage[MESH]
  • |Animals[MESH]
  • |Cell Differentiation[MESH]
  • |Humans[MESH]
  • |Interleukin-7/immunology/metabolism[MESH]
  • |Receptor, Notch1/immunology/metabolism[MESH]
  • |T-Lymphocytes/*cytology/*immunology[MESH]





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    *<b>[http://www.kidney.de/mlpefetch.php?search=20630771 Molecular and cellular basis of T cell lineage commitment ]</b> Semin Immunol 2010; 22(5) ; 270-5 Vicente R; Swainson L; Marty-Gres S; De Barros SC; Kinet S; Zimmermann VS; Taylor N

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    Semin Immunol

    270 5.22 2010