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lüll Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells Damle RN; Calissano C; Chiorazzi NBest Pract Res Clin Haematol 2010[Mar]; 23 (1): 33-45B cell-type chronic lymphocytic leukaemia (CLL) has long been considered a disease of resting lymphocytes. However, cell surface and intracellular phenotypes suggest that most CLL cells are activated cells, although only a small subset progresses beyond the G1 stage of the cell cycle. In addition, traditional teaching says that CLL cells divide rarely, and therefore the build-up of leukaemic cells is due to an inherent defect in cell death. However, in vivo labelling of CLL cells indicates a much more active rate of cell birth than originally estimated, suggesting that CLL is a dynamic disease. Here we review the observations that have led to these altered views of the activation state and proliferative capacities of CLL cells and also provide our interpretation of these observations in light of their potential impact on patients.|*Lymphocyte Activation[MESH]|B-Lymphocytes/*immunology/*pathology[MESH]|Cell Proliferation[MESH]|Humans[MESH]|Leukemia, Lymphocytic, Chronic, B-Cell/*immunology/*pathology[MESH]|Signal Transduction/immunology[MESH] |