Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Platelets as delivery systems for disease treatments Shi Q; Montgomery RRAdv Drug Deliv Rev 2010[Sep]; 62 (12): 1196-203Platelets are small, anucleate, discoid shaped blood cells that play a fundamental role in hemostasis. Platelets contain a large number of biologically active molecules within cytoplasmic granules that are critical to normal platelet function. Because platelets circulate in blood through out the body, release biological molecules and mediators on demand and participate in hemostasis as well as many other pathophysiologic processes, targeting expression of proteins of interest to platelets and utilizing platelets as delivery systems for disease treatment would be a logical approach. This paper reviews the genetic therapy for inherited bleeding disorders utilizing platelets as delivery system, with a particular focus on platelet-derived FVIII for hemophilia A treatment.|*Blood Platelets/metabolism[MESH]|*Genetic Therapy/adverse effects[MESH]|Animals[MESH]|Blood Coagulation[MESH]|Blood Coagulation Disorders/blood/metabolism/*therapy[MESH]|Cytoplasmic Granules[MESH]|Factor VIII/genetics/metabolism/*therapeutic use[MESH]|Hemophilia A/blood/genetics/metabolism/*therapy[MESH]|Hemophilia B/blood/genetics/metabolism/*therapy[MESH]|Hemostasis[MESH]|Humans[MESH]|Megakaryocytes/physiology[MESH]|Platelet Count[MESH] |