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  • Epigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspective
  • Zama AM; Uzumcu M
  • Front Neuroendocrinol 2010[Oct]; 31 (4): 420-39
  • The link between in utero and neonatal exposure to environmental toxicants, such as endocrine-disrupting chemicals (EDCs) and adult female reproductive disorders is well established in both epidemiological and animal studies. Recent studies examining the epigenetic mechanisms involved in mediating the effects of EDCs on female reproduction are gathering momentum. In this review, we describe the developmental processes that are susceptible to EDC exposures in female reproductive system, with a special emphasis on the ovary. We discuss studies with select EDCs that have been shown to have physiological and correlated epigenetic effects in the ovary, neuroendocrine system, and uterus. Importantly, EDCs that can directly target the ovary can alter epigenetic mechanisms in the oocyte, leading to transgenerational epigenetic effects. The potential mechanisms involved in such effects are also discussed.
  • |*Epigenomics[MESH]
  • |Animals[MESH]
  • |Endocrine Disruptors/*toxicity[MESH]
  • |Environmental Pollutants/toxicity[MESH]
  • |Female[MESH]
  • |Gene Expression Profiling[MESH]
  • |Genitalia, Female/drug effects/growth & development[MESH]
  • |Humans[MESH]
  • |Infertility, Female/*chemically induced/genetics[MESH]
  • |Male[MESH]
  • |Mice[MESH]
  • |Neurosecretory Systems/drug effects/growth & development[MESH]
  • |Ovary/*drug effects/growth & development[MESH]
  • |Receptors, Androgen/analysis[MESH]
  • |Receptors, Estrogen/analysis[MESH]
  • |Uterus/drug effects/growth & development[MESH]





  • *{{pmid20609371}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=20609371 Epigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspective ]</b> Front Neuroendocrinol 2010; 31(4) ; 420-39 Zama AM; Uzumcu M

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    Front Neuroendocrinol

    420 4.31 2010