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Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response Tichy A; Vavrova J; Pejchal J; Rezacova MActa Medica (Hradec Kralove) 2010[]; 53 (1): 13-7Ataxia-telangiectasia mutated kinase (ATM) is a DNA damage-inducible protein kinase, which phosphorylates plethora of substrates participating in DNA damage response. ATM significance for the cell faith is undeniable, since it regulates DNA repair, cell-cycle progress, and apoptosis. Here we describe its main signalling targets and discuss its importance in DNA repair as well as novel findings linked to this key regulatory enzyme in the terms of ionizing radiation-induced DNA damage.|*Mutation[MESH]|Ataxia Telangiectasia Mutated Proteins[MESH]|Ataxia Telangiectasia/genetics[MESH]|Cell Cycle Proteins/*genetics/physiology[MESH]|Cell Cycle/physiology[MESH]|DNA Damage/*radiation effects[MESH]|DNA Repair/*physiology[MESH]|DNA-Binding Proteins/*genetics/physiology[MESH]|Humans[MESH]|Protein Serine-Threonine Kinases/*genetics/physiology[MESH]|Tumor Suppressor Proteins/*genetics/physiology[MESH] |
