Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll International Union of Basic and Clinical Pharmacology LXXIV Apelin receptor nomenclature, distribution, pharmacology, and function Pitkin SL; Maguire JJ; Bonner TI; Davenport APPharmacol Rev 2010[Sep]; 62 (3): 331-42A gene encoding a novel class a G-protein-coupled receptor was discovered in 1993 by homology cloning and was called APJ. It was designated an "orphan" receptor until 1998, when its endogenous ligand was identified and named apelin (for APJ endogenous ligand). Since this pairing, both apelin and its receptor have been found to have a widespread distribution in both the central nervous system and the periphery. A number of physiological and pathophysiological roles for the receptor have emerged, including regulation of cardiovascular function, fluid homeostasis, and the adipoinsular axis. This review outlines the official International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification nomenclature, designating the receptor protein as the apelin receptor, together with current knowledge of its pharmacology, distribution, and functions.|Adipokines[MESH]|Animals[MESH]|Apelin[MESH]|Apelin Receptors[MESH]|Carrier Proteins/chemistry/classification/physiology[MESH]|Humans[MESH]|Intercellular Signaling Peptides and Proteins[MESH]|Rats[MESH]|Receptors, G-Protein-Coupled/chemistry/*classification/physiology[MESH]|Terminology as Topic[MESH] |