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V(D)J recombination: Born to be wild Ramsden DA; Weed BD; Reddy YVSemin Cancer Biol 2010[Aug]; 20 (4): 254-60Vertebrates employ V(D)J recombination to generate diversity for an adaptive immune response. Born of a transposon, V(D)J recombination could conceivably cause more trouble than its worth. However, of the two steps required for transposon mobility (excision and integration) this particular transposon's integration step appears mostly blocked in cells. The employment of a transposon as raw material to develop adaptive immunity was thus a less-risky choice than it might have been ... but is it completely risk-free?|*Recombination, Genetic[MESH]|Animals[MESH]|B-Lymphocytes/immunology/metabolism[MESH]|DNA Transposable Elements/genetics/physiology[MESH]|Gene Rearrangement/*genetics[MESH]|Humans[MESH]|Immunoglobulin Variable Region/*genetics/metabolism[MESH]|Models, Biological[MESH]|VDJ Recombinases/genetics/metabolism/*physiology[MESH] |
