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lüll Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death Laborde ECell Death Differ 2010[Sep]; 17 (9): 1373-80Glutathione transferases (GSTs) are enzymes that catalyze the conjugation of glutathione (GSH) to a variety of electrophilic substances. Their best known role is as cell housekeepers engaged in the detoxification of xenobiotics. Recently, GSTs have also been shown to act as modulators of signal transduction pathways that control cell proliferation and cell death. Their involvement in cancer cell growth and differentiation, and in the development of resistance to anticancer agents, has made them attractive drug targets. This review is focused on the inhibition of GSTs, in particular GSTP1-1, as a potential therapeutic approach for the treatment of cancer and other diseases associated with aberrant cell proliferation.|*Cell Proliferation[MESH]|Animals[MESH]|Cell Death[MESH]|Glutathione Transferase/antagonists & inhibitors/*metabolism[MESH]|Humans[MESH]|Neoplasms/drug therapy/metabolism[MESH]|Signal Transduction/*physiology[MESH] |